Version 5.4
Bos taurus Gene: FAM123B
Summary
InnateDB Gene IDBG-647200.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM123B
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008839
Encoded Proteins
IDBP-700044
family with sequence similarity 123B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184675:
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:101529564-101532923
Strand Forward strand
Band
Transcripts
ENSBTAT00000011639 ENSBTAP00000011639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008013 beta-catenin binding
Biological Process
GO:0001822 kidney development
GO:0060348 bone development
GO:0060612 adipose tissue development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000184675
View Gene Order
ENSMUSG00000050332
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_218396
Beta-catenin phosphorylation cascade pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BL05
UniProt Splice Variant
Entrez Gene 539029
UniGene Bt.88845
RefSeq XM_002700170 XM_005200792 XM_005228272 XM_584347
HUGO HGNC:26837
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02073449
GenPept
RNA Seq Atlas 539029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca