InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAP2B

Summary

InnateDB Gene

IDBG-647301.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP2B

Gene Name

ras-related protein Rap-2b

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016961

Encoded Proteins

IDBP-700139

ras-related protein Rap-2b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181467:
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50%% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:115476359-115480295

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022561

ENSBTAP00000052927

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030336	negative regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032486	Rap protein signal transduction
GO:0061097	regulation of protein tyrosine kinase activity

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000181467

View Gene Order

ENSMUSG00000036894

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A4IFU2

UniProt Splice Variant

Entrez Gene

784133

UniGene

Bt.22148

RefSeq

NM_001102531

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC134764 BC151263 DAAA02002606

GenPept

AAI34765 AAI51264

RNA Seq Atlas

784133