Version 5.4
Homo sapiens Gene: DGAT2
Summary
InnateDB Gene IDBG-64993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGAT2
Gene Name diacylglycerol O-acyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000062282
Encoded Proteins
IDBP-64995
diacylglycerol O-acyltransferase 2
IDBP-64997
diacylglycerol O-acyltransferase 2
IDBP-807513
diacylglycerol O-acyltransferase 2
IDBP-807514
diacylglycerol O-acyltransferase 2
IDBP-807549
diacylglycerol O-acyltransferase 2
IDBP-807552
diacylglycerol O-acyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:75759512-75801535
Strand Forward strand
Band q13.5
Transcripts
ENST00000228027 ENSP00000228027
ENST00000376262 ENSP00000365438
ENST00000603276 ENSP00000474015
ENST00000604935 ENSP00000474887
ENST00000605608
ENST00000604733 ENSP00000474668
ENST00000605099 ENSP00000475066
ENST00000603363
ENST00000603865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003846 2-acylglycerol O-acyltransferase activity
GO:0004144 diacylglycerol O-acyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803 protein homodimerization activity
GO:0050252 retinol O-fatty-acyltransferase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006644 phospholipid metabolic process
GO:0008152 metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0019915 lipid storage
GO:0034383 low-density lipoprotein particle clearance
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0035356 cellular triglyceride homeostasis
GO:0036155 acylglycerol acyl-chain remodeling
GO:0042572 retinol metabolic process
GO:0042632 cholesterol homeostasis
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046339 diacylglycerol metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0055089 fatty acid homeostasis
GO:0060613 fat pad development
GO:0071400 cellular response to oleic acid
GO:0097006 regulation of plasma lipoprotein particle levels
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030747
View Gene Order
ENSBTAG00000001154
Not yet available
Pathways
NETPATH
REACTOME
REACT_121122
Acyl chain remodeling of DAG and TAG pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00561
Glycerolipid metabolism pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q96PD7
TrEMBL S4R383 S4R3S3 S4R3Z3 S4R449
UniProt Splice Variant
Entrez Gene 84649
UniGene Hs.730240
RefSeq NM_001253891 NM_032564
HUGO HGNC:16940
OMIM 606983
CCDS CCDS31642 CCDS58162
HPRD
IMGT
EMBL AB048286 AB073384 AF384161 AL834287 AP001922 AP003031 AY358532 AY780647 BC015234 CR749377
GenPept AAH15234 AAK84176 AAQ88896 AAV35727 BAB40641 BAD38635 CAD38961 CAH18230
RNA Seq Atlas 84649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca