Version 5.4
Homo sapiens Gene: GCC2
Summary
InnateDB Gene IDBG-65024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCC2
Gene Name GRIP and coiled-coil domain containing 2
Synonyms GCC185; RANBP2L4; REN53
Species Homo sapiens
Ensembl Gene ENSG00000135968
Encoded Proteins
IDBP-65026
GRIP and coiled-coil domain containing 2
IDBP-243849
GRIP and coiled-coil domain containing 2
IDBP-294961
GRIP and coiled-coil domain containing 2
IDBP-294965
GRIP and coiled-coil domain containing 2
IDBP-384291
GRIP and coiled-coil domain containing 2
IDBP-484532
GRIP and coiled-coil domain containing 2
IDBP-809437
GRIP and coiled-coil domain containing 2
IDBP-809438
GRIP and coiled-coil domain containing 2
IDBP-809439
GRIP and coiled-coil domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:108448561-108509415
Strand Forward strand
Band q12.3
Transcripts
ENST00000309863 ENSP00000307939
ENST00000393321 ENSP00000376996
ENST00000409821 ENSP00000387350
ENST00000409896 ENSP00000386997
ENST00000447558 ENSP00000392470
ENST00000467566
ENST00000478207
ENST00000482325 ENSP00000419969
ENST00000485546
ENST00000462897 ENSP00000475234
ENST00000492785 ENSP00000475798
ENST00000481729
ENST00000480863
ENST00000614209 ENSP00000482844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000042 protein targeting to Golgi
GO:0006622 protein targeting to lysosome
GO:0031023 microtubule organizing center organization
GO:0034067 protein localization to Golgi apparatus
GO:0034453 microtubule anchoring
GO:0034499 late endosome to Golgi transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0070861 regulation of protein exit from endoplasmic reticulum
GO:0071955 recycling endosome to Golgi transport
GO:0090161 Golgi ribbon formation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038039
View Gene Order
ENSBTAG00000016038
Not yet available
Cross-References
SwissProt Q8IWJ2
TrEMBL B3KR21 B8ZZA5 B8ZZW2 H7BYJ9 U3KPU4
UniProt Splice Variant
Entrez Gene 9648
UniGene Hs.436505 Hs.670547 Hs.688226
RefSeq NM_181453 XM_006712870 XM_006712871
HUGO HGNC:23218
OMIM 612711
CCDS CCDS33268
HPRD
IMGT
EMBL AB002334 AC012487 AC068941 AF273042 AF432211 AK090813 BC037774 BC146789 CH471182
GenPept AAG34902 AAH37774 AAI46790 AAL99918 AAX88838 BAA20794 BAG52233 EAW53882
RNA Seq Atlas 9648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca