Version 5.4
Homo sapiens Gene: KLK4
Summary
InnateDB Gene IDBG-65132.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK4
Gene Name kallikrein-related peptidase 4
Synonyms AI2A1; ARM1; EMSP; EMSP1; kallikrein; KLK-L1; PRSS17; PSTS
Species Homo sapiens
Ensembl Gene ENSG00000167749
Encoded Proteins
IDBP-65134
kallikrein-related peptidase 4
IDBP-383925
kallikrein-related peptidase 4
IDBP-766075
IDBP-764328
IDBP-759733
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50906352-50910738
Strand Reverse strand
Band q13.41
Transcripts
ENST00000324041 ENSP00000326159
ENST00000431178 ENSP00000399448
ENST00000599865
ENST00000596876
ENST00000593885 ENSP00000469769
ENST00000597441
ENST00000598305 ENSP00000469963
ENST00000602148 ENSP00000472091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030163 protein catabolic process
GO:0097186 amelogenesis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006948
View Gene Order
ENSBTAG00000020415
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Cross-References
SwissProt
TrEMBL M0QYN5
UniProt Splice Variant
Entrez Gene 9622
UniGene Hs.579933
RefSeq NM_004917 XM_005259441
HUGO HGNC:6365
OMIM 603767
CCDS CCDS12809
HPRD 04793
IMGT
EMBL AC011483
GenPept
RNA Seq Atlas 9622

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca