Version 5.4
Homo sapiens Gene: CAPN5
Summary
InnateDB Gene IDBG-65276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN5
Gene Name calpain 5
Synonyms ADNIV; HTRA3; nCL-3; VRNI
Species Homo sapiens
Ensembl Gene ENSG00000149260
Encoded Proteins
IDBP-65278
calpain 5
IDBP-381292
calpain 5
IDBP-718436
IDBP-595611
calpain 5
IDBP-594524
calpain 5
IDBP-807533
calpain 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:77066932-77126155
Strand Forward strand
Band q13.5
Transcripts
ENST00000278559 ENSP00000278559
ENST00000456580 ENSP00000409996
ENST00000531028 ENSP00000467244
ENST00000527066 ENSP00000435894
ENST00000529629 ENSP00000432332
ENST00000533889
ENST00000527129
ENST00000615896 ENSP00000483282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035547
View Gene Order
ENSBTAG00000005034
Not yet available
Cross-References
SwissProt
TrEMBL E9PS73
UniProt Splice Variant
Entrez Gene 726
UniGene
RefSeq NM_004055
HUGO HGNC:1482
OMIM 602537
CCDS CCDS8248
HPRD
IMGT
EMBL AP000752
GenPept
RNA Seq Atlas 726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca