Version 5.4
Homo sapiens Gene: SIGLEC10
Summary
InnateDB Gene IDBG-65888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC10
Gene Name sialic acid binding Ig-like lectin 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142512
Encoded Proteins
IDBP-65890
sialic acid binding Ig-like lectin 10
IDBP-65892
sialic acid binding Ig-like lectin 10
IDBP-384089
sialic acid binding Ig-like lectin 10
IDBP-384090
sialic acid binding Ig-like lectin 10
IDBP-384091
sialic acid binding Ig-like lectin 10
IDBP-384092
sialic acid binding Ig-like lectin 10
IDBP-589765
sialic acid binding Ig-like lectin 10
IDBP-603924
sialic acid binding Ig-like lectin 10
IDBP-589552
sialic acid binding Ig-like lectin 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC10 is a member of the SIGLEC protein family that recognize sialoside-based patterns and responds selectively to danger associated molecular patterns (DAMPs) to initiate limited innate response.
Entrez Gene
Summary SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51410021-51417803
Strand Reverse strand
Band q13.41
Transcripts
ENST00000357375
ENST00000353836 ENSP00000342389
ENST00000339313 ENSP00000345243
ENST00000439889 ENSP00000389132
ENST00000442846 ENSP00000395475
ENST00000436984 ENSP00000414324
ENST00000441969 ENSP00000408387
ENST00000525998 ENSP00000431444
ENST00000529627 ENSP00000435281
ENST00000530476 ENSP00000433838
ENST00000524527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001171156 NM_001171157 NM_001171158 NM_001171159 NM_001171161 NM_033130 XM_005259369
HUGO
OMIM
CCDS CCDS12832 CCDS54301 CCDS54302 CCDS54303 CCDS54304 CCDS54305
HPRD 07307
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca