Version 5.4
Homo sapiens Gene: ZMAT3
Summary
InnateDB Gene IDBG-65982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZMAT3
Gene Name zinc finger, matrin-type 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172667
Encoded Proteins
IDBP-65984
zinc finger, matrin-type 3
IDBP-385581
zinc finger, matrin-type 3
IDBP-385589
zinc finger, matrin-type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:179017223-179072279
Strand Reverse strand
Band q26.32
Transcripts
ENST00000311417 ENSP00000311221
ENST00000432729 ENSP00000396506
ENST00000414084 ENSP00000398920
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0015031 protein transport
GO:0040008 regulation of growth
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027663
View Gene Order
ENSBTAG00000012463
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9J8H5
UniProt Splice Variant
Entrez Gene 64393
UniGene Hs.371609 Hs.595606 Hs.596929 Hs.611263
RefSeq NM_022470 NM_152240 XM_005247706 XM_006713725 XM_006713726
HUGO HGNC:29983
OMIM 606452
CCDS CCDS3224 CCDS46962
HPRD 07343
IMGT
EMBL AC117456
GenPept
RNA Seq Atlas 64393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca