Version 5.4
Homo sapiens Gene: KCNJ16
Summary
InnateDB Gene IDBG-66545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ16
Gene Name potassium inwardly-rectifying channel, subfamily J, member 16
Synonyms BIR9; KIR5.1
Species Homo sapiens
Ensembl Gene ENSG00000153822
Encoded Proteins
IDBP-66547
potassium inwardly-rectifying channel, subfamily J, member 16
IDBP-245185
potassium inwardly-rectifying channel, subfamily J, member 16
IDBP-245187
potassium inwardly-rectifying channel, subfamily J, member 16
IDBP-764905
IDBP-758999
IDBP-760870
IDBP-763538
IDBP-760758
IDBP-763004
IDBP-812886
potassium inwardly-rectifying channel, subfamily J, member 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:70053429-70135608
Strand Forward strand
Band q24.3
Transcripts
ENST00000283936 ENSP00000283936
ENST00000392671 ENSP00000376439
ENST00000392670 ENSP00000376438
ENST00000588112
ENST00000587892 ENSP00000465163
ENST00000591891 ENSP00000465646
ENST00000586462 ENSP00000467568
ENST00000589377 ENSP00000465967
ENST00000587698 ENSP00000466132
ENST00000585558 ENSP00000465295
ENST00000615244 ENSP00000479817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051497
View Gene Order
ENSBTAG00000024903
Not yet available
Pathways
NETPATH
REACTOME
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_75815
Potassium transport channels pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q9NPI9
TrEMBL K7EKJ4 K7ELL5
UniProt Splice Variant
Entrez Gene 3773
UniGene Hs.463985 Hs.613753
RefSeq NM_001270422 NM_001291622 NM_001291623 NM_001291624 NM_001291625 NM_018658 NM_170741 NM_170742 XM_005257334 XM_005257335 XM_005257336 XM_005257337 XM_006721882 XM_006721883 XM_006721884 XM_006721885 XM_006721886 XM_006721887 XM_006721888 XM_006721889 XM_006721890
HUGO HGNC:6262
OMIM 605722
CCDS CCDS11687 CCDS74141
HPRD 16146
IMGT
EMBL AC005208 AF153814 AF153815 AF153816 AF153817 AF179353
GenPept AAF73238 AAF73239 AAF73240 AAF73244 AAG09401
RNA Seq Atlas 3773

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca