Homo sapiens Gene: UVSSA

Summary
InnateDB Gene IDBG-6670.6
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol UVSSA
Gene Name UV-stimulated scaffold protein A
Synonyms KIAA1530; UVSS3
Species Homo sapiens
Ensembl Gene ENSG00000163945
Encoded Proteins
IDBP-6672 KIAA1530
IDBP-479952 KIAA1530
IDBP-482751 KIAA1530
IDBP-477617 KIAA1530
IDBP-476314 KIAA1530
IDBP-477652 KIAA1530
Entrez Gene
Summary The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex to help repair UV-induced DNA damage. Defects in this gene can cause UV-sensitive syndrome 3. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4: 1341054-1381837
Strand Forward strand
Band p16.3
Transcripts
ENST00000389851  ENSP00000374501
ENST00000511216  ENSP00000425130
ENST00000507531  ENSP00000421741
ENST00000505716 
ENST00000511563  ENSP00000423340
ENST00000512728  ENSP00000427701
ENST00000503548  ENSP00000422795
ENST00000507422 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein‑Protein  10
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0000993 RNA polymerase II core binding
GO:0005515 protein binding
Biological Process
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0009411 response to UV
GO:0016567 protein ubiquitination
Cellular Component
GO:0044427 chromosomal part
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000037355 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000012577 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q2YD98 
TrEMBL Q69YU2
UniProt Splice Variant
Entrez Gene 57654 
UniGene Hs.380475
RefSeq NM_020894 
HUGO 29304 
OMIM 614632
CCDS CCDS33938 
HPRD 17216
IMGT
EMBL AB040963 AC078852 AC118281 AK292661 AL390128 BC021930 BC110331 BC140901
GenPept AAH21930  AAI10332  AAI40902  BAA96054  BAF85350  CAH10662 
ImmGen UVSSA (murine) 
RNA Seq Atlas 57654