Version 5.4
Homo sapiens Gene: CRIPAK
Summary
InnateDB Gene IDBG-6714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRIPAK
Gene Name cysteine-rich PAK1 inhibitor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179979
Encoded Proteins
IDBP-6716
cysteine-rich PAK1 inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 [PubMed 16278681]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:1391552-1395989
Strand Forward strand
Band p16.3
Transcripts
ENST00000324803 ENSP00000323978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0043627 response to estrogen
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q8N1N5
TrEMBL
UniProt Splice Variant
Entrez Gene 285464
UniGene Hs.26410 Hs.610327 Hs.615247 Hs.619536
RefSeq NM_175918
HUGO HGNC:26619
OMIM 610203
CCDS CCDS3349
HPRD
IMGT
EMBL AK091762 AK096209
GenPept BAC03741 BAC04725
RNA Seq Atlas 285464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca