Version 5.4
Homo sapiens Gene: DPP10
Summary
InnateDB Gene IDBG-67408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPP10
Gene Name dipeptidyl-peptidase 10 (non-functional)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175497
Encoded Proteins
IDBP-67410
dipeptidyl-peptidase 10 (non-functional)
IDBP-244195
dipeptidyl-peptidase 10 (non-functional)
IDBP-244197
dipeptidyl-peptidase 10 (non-functional)
IDBP-294619
dipeptidyl-peptidase 10 (non-functional)
IDBP-294617
dipeptidyl-peptidase 10 (non-functional)
IDBP-385084
dipeptidyl-peptidase 10 (non-functional)
IDBP-385086
dipeptidyl-peptidase 10 (non-functional)
IDBP-385087
dipeptidyl-peptidase 10 (non-functional)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:114442299-115845752
Strand Forward strand
Band q14.1
Transcripts
ENST00000310323 ENSP00000309066
ENST00000393147 ENSP00000376855
ENST00000393146 ENSP00000376854
ENST00000410059 ENSP00000386565
ENST00000409163 ENSP00000387038
ENST00000436732 ENSP00000391092
ENST00000429914 ENSP00000408535
ENST00000419287 ENSP00000402499
ENST00000461250
ENST00000492708
ENST00000486885
ENST00000488208
ENST00000473362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036815
View Gene Order
ENSBTAG00000005235
Not yet available
Cross-References
SwissProt Q8N608
TrEMBL C9J4M8 J3KQK8
UniProt Splice Variant
Entrez Gene 57628
UniGene Hs.657379
RefSeq NM_001178034 NM_001004360 NM_001178036 NM_001178037 NM_020868 XM_005263718
HUGO HGNC:20823
OMIM 608209
CCDS CCDS54388 CCDS33278 CCDS46400 CCDS54389
HPRD 07083
IMGT
EMBL AB040925 AC010885 AC012071 AC016721 AC017040 AC066593 AC067947 AC068542 AC093610 AC105422 AC116620 AC118276 AC118664 AK289967 AY172661 AY387785 BC030832 DQ857322
GenPept AAH30832 AAO17263 AAQ91190 AAY14685 AAY15025 AAY15032 AAY24120 ABI16086 BAA96016 BAF82656
RNA Seq Atlas 57628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca