Version 5.4
Homo sapiens Gene: HIST1H1E
Summary
InnateDB Gene IDBG-67975.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1E
Gene Name histone cluster 1, H1e
Synonyms dJ221C16.5; H1.4; H1E; H1F4; H1s-4
Species Homo sapiens
Ensembl Gene ENSG00000168298
Encoded Proteins
IDBP-67977
histone cluster 1, H1e
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26156391-26157050
Strand Forward strand
Band p22.2
Transcripts
ENST00000304218 ENSP00000307705
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0016584 nucleosome positioning
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051627
View Gene Order
ENSBTAG00000047206
Not yet available
Pathways
NETPATH
REACTOME
REACT_13462
Activation of DNA fragmentation factor pathway
REACT_995
Apoptotic execution phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_1213
Apoptosis induced DNA fragmentation pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_578
Apoptosis pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
KEGG
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt P10412
TrEMBL A3R0T8
UniProt Splice Variant
Entrez Gene 3008
UniGene
RefSeq NM_005321
HUGO HGNC:4718
OMIM 142220
CCDS CCDS4586
HPRD
IMGT
EMBL AF531302 AL353759 BC096168 BC096169 BC099632 CH471087 EF065555 M60748
GenPept AAA63187 AAH96168 AAH96169 AAH99632 AAN06702 ABN72277 CAC04132 EAW55534
RNA Seq Atlas 3008

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca