InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED17

Summary

InnateDB Gene

IDBG-68107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED17

Gene Name

mediator complex subunit 17

Synonyms

CRSP6; CRSP77; DRIP80; TRAP80

Species

Homo sapiens

Ensembl Gene

ENSG00000042429

Encoded Proteins

IDBP-68109

mediator complex subunit 17

IDBP-590895

mediator complex subunit 17

IDBP-583207

mediator complex subunit 17

IDBP-585629

mediator complex subunit 17

IDBP-595682

mediator complex subunit 17

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:93784227-93814695

Strand

Forward strand

Band

q21

Transcripts

ENST00000251871	ENSP00000251871
ENST00000507258
ENST00000530819	ENSP00000434459
ENST00000533359	ENSP00000431524
ENST00000533133	ENSP00000433090
ENST00000528786	ENSP00000433626
ENST00000525026
ENST00000533367
ENST00000531920
ENST00000525613
ENST00000529626

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	85 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809	vitamin D receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter