Homo sapiens Gene: HIST1H2BE
Summary
InnateDB Gene IDBG-68115.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol HIST1H2BE
Gene Name histone cluster 1, H2be
Synonyms dJ221C16.8; H2B.h; H2B/h; H2BFH;
Species Homo sapiens
Ensembl Gene ENSG00000197697
Encoded Proteins
histone cluster 1, H2be
Protein Structure
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26183958-26184454
Strand Forward strand
Band p22.2
Transcripts
ENST00000356530 ENSP00000348924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0042742 defense response to bacterium
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P62807
TrEMBL B2R4S9
UniProt Splice Variant
Entrez Gene 8347
UniGene Hs.534369
RefSeq NM_003523
HUGO 4753
OMIM 602798 602804 602805 602807 602847
CCDS CCDS4588
HPRD 11901
IMGT
EMBL AF531286 AF531288 AF531289 AF531290 AF531292 AK311935 AK312096 AL031777 AL353759 BC001131 BC009612 BC096120 BC096122 BC096123 BC101653 BC101655 BC101748 BC101750 BC106899 CH471087 M60750 Z80779 Z80780 Z80782 Z80783
GenPept AAA63189 AAH96120 AAH96122 AAH96123 AAI01654 AAI01656 AAI01749 AAI01751 AAI06900 AAN06686 AAN06688 AAN06689 AAN06690 AAN06692 BAG34876 BAG35032 CAB02541 CAB02542 CAB02544 CAB02545 CAC03411 CAC03417 CAC03420 CAC04130 EAW55530 EAW55537 EAW55543 EAW55545 EAW55554
ImmGen HIST1H2BE (murine)
RNA Seq Atlas 8339 8343 8344 8346 8347