Homo sapiens Gene: HIST1H2BE

Summary
InnateDB Gene IDBG-68115.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol HIST1H2BE
Gene Name histone cluster 1, H2be
Synonyms dJ221C16.8; H2B.h; H2B/h; H2BFH
Species Homo sapiens
Ensembl Gene ENSG00000197697
Encoded Proteins
IDBP-68117 histone cluster 1, H2be
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 26183958-26184454
Strand Forward strand
Band p22.2
Transcripts
ENST00000356530  ENSP00000348924
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein‑Protein  20
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0042742 defense response to bacterium
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P62807 
TrEMBL B2R4S9
UniProt Splice Variant
Entrez Gene 8339  8343  8344  8346  8347 
UniGene Hs.534369
RefSeq NM_003523 
HUGO 4753 
OMIM 602798 602804 602805 602807 602847
CCDS CCDS4588 
HPRD 11901
IMGT
EMBL AF531286 AF531288 AF531289 AF531290 AF531292 AK311935 AK312096 AL031777 AL353759 BC001131 BC009612 BC096120 BC096122 BC096123 BC101653 BC101655 BC101748 BC101750 BC106899 CH471087 M60750 Z80779 Z80780 Z80782 Z80783
GenPept AAA63189  AAH96120  AAH96122  AAH96123  AAI01654  AAI01656  AAI01749  AAI01751  AAI06900  AAN06686  AAN06688  AAN06689  AAN06690  AAN06692  BAG34876  BAG35032  CAB02541  CAB02542  CAB02544  CAB02545  CAC03411  CAC03417  CAC03420  CAC04130  EAW55530  EAW55537  EAW55543  EAW55545  EAW55554 
ImmGen HIST1H2BE (murine) 
RNA Seq Atlas 8339  8343  8344  8346  8347