Homo sapiens Gene: HIST1H4D

Summary
InnateDB Gene IDBG-68182.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol HIST1H4D
Gene Name histone cluster 1, H4d
Synonyms dJ221C16.9; H4/b; H4FB
Species Homo sapiens
Ensembl Gene ENSG00000188987
Encoded Proteins
IDBP-68184 histone cluster 1, H4d
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 26188938-26189304
Strand Reverse strand
Band p22.2
Transcripts
ENST00000340756  ENSP00000343282
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein‑Protein  17
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006352 DNA-dependent transcription, initiation
GO:0034080 CenH3-containing nucleosome assembly at centromere
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0015629 actin cytoskeleton
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P62805 
TrEMBL B2R4R0 Q6B823
UniProt Splice Variant
Entrez Gene 121504  554313  8294  8359  8360  8361  8362  8363  8364  8365  8366  8367  8368  8370 
UniGene
RefSeq NM_003539 
HUGO 4782 
OMIM 142750 602822 602823 602824 602825 602826 602827 602828 602829 602830 602831 602833
CCDS CCDS4589 
HPRD 11914
IMGT
EMBL AB000905 AB451459 AF525682 AK311916 AK312028 AK312153 AK316561 AL021807 AL021917 AL031777 AL049822 AL353759 AL591493 AY128653 AY128654 AY128655 AY128656 AY128657 AY128658 AY128659 AY128661 AY128662 AY128663 AY128664 AY128665 AY648850 AY675271 AY675295 BC017361 BC054014 BC066248 BC066249 BC066250 BC067495 BC067496 BC067497 BC069288 BC069392 BC069467 BC069654 BC093763 BC093765 BC093969 BC111093 BC111434 BC112193 BC120939 BC128104 BC128105 BC130558 BC130560 BC143045 BC148271 CH471081 CH471087 CH471094 CR542169 CR542172 CR542180 CR542187 CR542189 M16707 M60749 X00038 X60481 X60482 X60483 X60484 X60486 X60487 X67081 X83548 Z80787 Z98744
GenPept AAA52652  AAA63188  AAH17361  AAH54014  AAH66248  AAH66249  AAH66250  AAH67495  AAH67496  AAH67497  AAH69288  AAH69392  AAH69467  AAH69654  AAH93763  AAH93765  AAH93969  AAI11094  AAI11435  AAI12194  AAI20940  AAI28105  AAI28106  AAI30559  AAI30561  AAI43046  AAI48272  AAM83108  AAN01438  AAN01439  AAN01440  AAN01441  AAN01442  AAN01443  AAN01444  AAN01446  AAN01447  AAN01448  AAN01449  AAN01450  AAT68253  AAT78448  AAT78472  BAA19208  BAG34857  BAG34965  BAG35087  BAG38150  BAG70273  CAA16946  CAA24918  CAA43011  CAA43012  CAA43013  CAA43014  CAA43016  CAA43017  CAA47464  CAA58538  CAB02549  CAC03414  CAC03418  CAC03426  CAC03427  CAC04128  CAC69642  CAD24074  CAG46966  CAG46969  CAG46977  CAG46984  CAG46986  CAI12560  CAI12567  EAW55509  EAW55510  EAW55538  EAW55549  EAW55555  EAW96325  EAX03086  EAX03111  EAX03112  EAX03121 
ImmGen HIST1H4D (murine) 
RNA Seq Atlas 121504  554313  8294  8359  8360  8361  8362  8363  8364  8365  8366  8367  8368  8370