Homo sapiens Gene: HIST1H4D
Summary
InnateDB Gene IDBG-68182.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol HIST1H4D
Gene Name histone cluster 1, H4d
Synonyms dJ221C16.9; H4/b; H4FB;
Species Homo sapiens
Ensembl Gene ENSG00000188987
Encoded Proteins
histone cluster 1, H4d
Protein Structure
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26188938-26189304
Strand Reverse strand
Band p22.2
Transcripts
ENST00000340756 ENSP00000343282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006352 DNA-dependent transcription, initiation
GO:0034080 CenH3-containing nucleosome assembly at centromere
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0015629 actin cytoskeleton
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P62805
TrEMBL B2R4R0 Q6B823
UniProt Splice Variant
Entrez Gene 8370
UniGene
RefSeq NM_003539
HUGO 4782
OMIM 142750 602822 602823 602824 602825 602826 602827 602828 602829 602830 602831 602833
CCDS CCDS4589
HPRD 11914
IMGT
EMBL AB000905 AB451459 AF525682 AK311916 AK312028 AK312153 AK316561 AL021807 AL021917 AL031777 AL049822 AL353759 AL591493 AY128653 AY128654 AY128655 AY128656 AY128657 AY128658 AY128659 AY128661 AY128662 AY128663 AY128664 AY128665 AY648850 AY675271 AY675295 BC017361 BC054014 BC066248 BC066249 BC066250 BC067495 BC067496 BC067497 BC069288 BC069392 BC069467 BC069654 BC093763 BC093765 BC093969 BC111093 BC111434 BC112193 BC120939 BC128104 BC128105 BC130558 BC130560 BC143045 BC148271 CH471081 CH471087 CH471094 CR542169 CR542172 CR542180 CR542187 CR542189 M16707 M60749 X00038 X60481 X60482 X60483 X60484 X60486 X60487 X67081 X83548 Z80787 Z98744
GenPept AAA52652 AAA63188 AAH17361 AAH54014 AAH66248 AAH66249 AAH66250 AAH67495 AAH67496 AAH67497 AAH69288 AAH69392 AAH69467 AAH69654 AAH93763 AAH93765 AAH93969 AAI11094 AAI11435 AAI12194 AAI20940 AAI28105 AAI28106 AAI30559 AAI30561 AAI43046 AAI48272 AAM83108 AAN01438 AAN01439 AAN01440 AAN01441 AAN01442 AAN01443 AAN01444 AAN01446 AAN01447 AAN01448 AAN01449 AAN01450 AAT68253 AAT78448 AAT78472 BAA19208 BAG34857 BAG34965 BAG35087 BAG38150 BAG70273 CAA16946 CAA24918 CAA43011 CAA43012 CAA43013 CAA43014 CAA43016 CAA43017 CAA47464 CAA58538 CAB02549 CAC03414 CAC03418 CAC03426 CAC03427 CAC04128 CAC69642 CAD24074 CAG46966 CAG46969 CAG46977 CAG46984 CAG46986 CAI12560 CAI12567 EAW55509 EAW55510 EAW55538 EAW55549 EAW55555 EAW96325 EAX03086 EAX03111 EAX03112 EAX03121
ImmGen HIST1H4D (murine)
RNA Seq Atlas 121504 554313 8294 8359 8360 8361 8362 8363 8364 8365 8366 8367 8368 8370