Homo sapiens Gene: HIST1H3D
Summary
InnateDB Gene IDBG-68256.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol HIST1H3D
Gene Name histone cluster 1, H3d
Synonyms H3/b; H3FB;
Species Homo sapiens
Ensembl Gene ENSG00000197409
Encoded Proteins
histone cluster 1, H3d
histone cluster 1, H3d
Protein Structure
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26197068-26199521
Strand Reverse strand
Band p22.2
Transcripts
ENST00000377831 ENSP00000367062
ENST00000356476 ENSP00000366999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0007596 blood coagulation
GO:0051320 S phase
GO:0060968 regulation of gene silencing
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005654 nucleoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P68431
TrEMBL
UniProt Splice Variant
Entrez Gene 8968
UniGene Hs.532144
RefSeq NM_003530
HUGO 4767
OMIM 602810 602811 602812 602813 602814 602815 602816 602817 602818 602819
CCDS CCDS4590
HPRD 11905
IMGT
EMBL AF531274 AF531275 AF531276 AF531277 AF531278 AF531279 AF531280 AF531281 AF531282 AF531283 AK311991 AK313905 AK314142 AK316611 AL009179 AL031777 BC031333 BC066245 BC066246 BC066247 BC066884 BC067490 BC067491 BC067492 BC067493 BC069133 BC069303 BC069305 BC069818 BC096128 BC096129 BC096130 BC096131 BC096132 BC096133 BC096134 BC099630 BC127610 BC143046 BC148243 BC148250 CR541858 CR541983 CR542011 CR542014 M26150 M60746 X00090 X57128 X83550 Z46261 Z80784 Z80785 Z80786 Z83735 Z83737 Z98744
GenPept AAA52651 AAA63185 AAH31333 AAH66245 AAH66246 AAH66247 AAH66884 AAH67490 AAH67491 AAH67492 AAH67493 AAH69133 AAH69303 AAH69305 AAH69818 AAH96128 AAH96129 AAH96130 AAH96131 AAH96132 AAH96133 AAH96134 AAH99630 AAI27611 AAI43047 AAI48244 AAI48251 AAN10051 AAN10052 AAN10053 AAN10054 AAN10055 AAN10056 AAN10057 AAN10058 AAN10059 AAN10060 BAG34929 BAG36628 BAG36832 BAG38198 CAA15670 CAA24952 CAA40407 CAA58540 CAA86403 CAB02546 CAB02547 CAB02548 CAB06030 CAB06032 CAB11424 CAC03412 CAC03413 CAC03416 CAC03421 CAD24076 CAG46656 CAG46780 CAG46808 CAG46811
ImmGen HIST1H3D (murine)
RNA Seq Atlas 8350 8351 8352 8353 8354 8355 8356 8357 8358 8968