Homo sapiens Gene: HIST1H3D

Summary
InnateDB Gene IDBG-68256.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol HIST1H3D
Gene Name histone cluster 1, H3d
Synonyms H3/b; H3FB
Species Homo sapiens
Ensembl Gene ENSG00000197409
Encoded Proteins
IDBP-66774 histone cluster 1, H3d
IDBP-68258 histone cluster 1, H3d
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 26197068-26199521
Strand Reverse strand
Band p22.2
Transcripts
ENST00000377831  ENSP00000367062
ENST00000356476  ENSP00000366999
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein‑Protein  4
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0007596 blood coagulation
GO:0051320 S phase
GO:0060968 regulation of gene silencing
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005654 nucleoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P68431 
TrEMBL
UniProt Splice Variant
Entrez Gene 8350  8351  8352  8353  8354  8355  8356  8357  8358  8968 
UniGene Hs.532144
RefSeq NM_003530 
HUGO 4767 
OMIM 602810 602811 602812 602813 602814 602815 602816 602817 602818 602819
CCDS CCDS4590 
HPRD 11905
IMGT
EMBL AF531274 AF531275 AF531276 AF531277 AF531278 AF531279 AF531280 AF531281 AF531282 AF531283 AK311991 AK313905 AK314142 AK316611 AL009179 AL031777 BC031333 BC066245 BC066246 BC066247 BC066884 BC067490 BC067491 BC067492 BC067493 BC069133 BC069303 BC069305 BC069818 BC096128 BC096129 BC096130 BC096131 BC096132 BC096133 BC096134 BC099630 BC127610 BC143046 BC148243 BC148250 CR541858 CR541983 CR542011 CR542014 M26150 M60746 X00090 X57128 X83550 Z46261 Z80784 Z80785 Z80786 Z83735 Z83737 Z98744
GenPept AAA52651  AAA63185  AAH31333  AAH66245  AAH66246  AAH66247  AAH66884  AAH67490  AAH67491  AAH67492  AAH67493  AAH69133  AAH69303  AAH69305  AAH69818  AAH96128  AAH96129  AAH96130  AAH96131  AAH96132  AAH96133  AAH96134  AAH99630  AAI27611  AAI43047  AAI48244  AAI48251  AAN10051  AAN10052  AAN10053  AAN10054  AAN10055  AAN10056  AAN10057  AAN10058  AAN10059  AAN10060  BAG34929  BAG36628  BAG36832  BAG38198  CAA15670  CAA24952  CAA40407  CAA58540  CAA86403  CAB02546  CAB02547  CAB02548  CAB06030  CAB06032  CAB11424  CAC03412  CAC03413  CAC03416  CAC03421  CAD24076  CAG46656  CAG46780  CAG46808  CAG46811 
ImmGen HIST1H3D (murine) 
RNA Seq Atlas 8350  8351  8352  8353  8354  8355  8356  8357  8358  8968