InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INHBB

Summary

InnateDB Gene

IDBG-68259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHBB

Gene Name

inhibin, beta B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163083

Encoded Proteins

IDBP-68261

inhibin, beta B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:120346143-120351808

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000295228

ENSP00000295228

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity
GO:0046789	host cell surface receptor binding

Biological Process

GO:0001541	ovarian follicle development
GO:0006952	defense response
GO:0009267	cellular response to starvation
GO:0009612	response to mechanical stimulus
GO:0030154	cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0044320	cellular response to leptin stimulus
GO:0045444	fat cell differentiation
GO:0046676	negative regulation of insulin secretion
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0048178	negative regulation of hepatocyte growth factor biosynthetic process
GO:0048599	oocyte development
GO:0060279	positive regulation of ovulation
GO:2001235	positive regulation of apoptotic signaling pathway