Version 5.4
Homo sapiens Gene: GRB2
Summary
InnateDB Gene IDBG-68262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB2
Gene Name growth factor receptor-bound protein 2
Synonyms ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2
Species Homo sapiens
Ensembl Gene ENSG00000177885
Encoded Proteins
IDBP-68264
growth factor receptor-bound protein 2
IDBP-68266
growth factor receptor-bound protein 2
IDBP-245404
growth factor receptor-bound protein 2
IDBP-245406
growth factor receptor-bound protein 2
IDBP-245408
growth factor receptor-bound protein 2
IDBP-763335
IDBP-759687
IDBP-757808
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75318076-75405709
Strand Reverse strand
Band q25.1
Transcripts
ENST00000316804 ENSP00000339007
ENST00000316615 ENSP00000317360
ENST00000392564 ENSP00000376347
ENST00000392563 ENSP00000376346
ENST00000392562 ENSP00000376345
ENST00000462266
ENST00000581959 ENSP00000463525
ENST00000583912
ENST00000582582 ENSP00000462785
ENST00000578961 ENSP00000464279
ENST00000577711
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 663 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Experimentally validated
Total 663 [view]
Protein-Protein 660 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043560 insulin receptor substrate binding
GO:0044822 poly(A) RNA binding
GO:0046875 ephrin receptor binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0007568 aging
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0016032 viral process
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031623 receptor internalization
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770 signal transduction in response to DNA damage
GO:0043408 regulation of MAPK cascade
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050900 leukocyte migration
GO:0051291 protein heterooligomerization
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0071479 cellular response to ionizing radiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0070436 Grb2-EGFR complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059923
View Gene Order
ENSBTAG00000004736
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_20
IL9 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04912
GnRH signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04540
Gap junction pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa05213
Endometrial cancer pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04320
Dorso-ventral axis formation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04380
Osteoclast differentiation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
il2_1pathway
IL2-mediated signaling events
erbb4_pathway
ErbB4 signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
erbb1_internalization_pathway
Internalization of ErbB1
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
ptp1bpathway
Signaling events mediated by PTP1B
erbb1_downstream_pathway
ErbB1 downstream signaling
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
epopathway
EPO signaling pathway
ephbfwdpathway
EPHB forward signaling
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
fgf_pathway
FGF signaling pathway
bcr_5pathway
BCR signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
et_egfrpathway
EGFR-dependent Endothelin signaling events
tcptp_pathway
Signaling events mediated by TCPTP
ras_pathway
Regulation of Ras family activation
il4_2pathway
IL4-mediated signaling events
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
il3_pathway
IL3-mediated signaling events
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
tgfbrpathway
TGF-beta receptor signaling
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
gmcsf_pathway
GMCSF-mediated signaling events
epha2_fwdpathway
EPHA2 forward signaling
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
pdgfrapathway
PDGFR-alpha signaling pathway
il2_pi3kpathway
IL2 signaling events mediated by PI3K
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
insulin_pathway
Insulin Pathway
il5_pathway
IL5-mediated signaling events
Cross-References
SwissProt P62993
TrEMBL B0LPF3 J3KT38
UniProt Splice Variant
Entrez Gene 2885
UniGene Hs.444356
RefSeq NM_002086 NM_203506
HUGO HGNC:4566
OMIM 108355
CCDS CCDS11721 CCDS11722
HPRD 00150
IMGT
EMBL AC011933 AF063614 AF063615 AF063616 AF063617 AF063618 AF498925 AK315565 BC000631 CH471099 CR541942 EU332843 JX512444 L29511 M96995 X62852
GenPept AAA58448 AAC37549 AAC72075 AAH00631 AAM21073 ABY87532 AGC09591 BAG37940 CAA44664 CAG46740 EAW89270
RNA Seq Atlas 2885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca