Version 5.4
Homo sapiens Gene: PARD3
Summary
InnateDB Gene IDBG-69007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARD3
Gene Name par-3 partitioning defective 3 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148498
Encoded Proteins
IDBP-69009
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69011
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69013
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69015
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69017
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69019
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69021
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69023
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69025
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-69027
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-591372
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-600012
par-3 partitioning defective 3 homolog (C. elegans)
IDBP-586667
par-3 partitioning defective 3 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24244864
Atypical PKC and PARD3 are inhibitors of the canonical NF-κB activation pathway in epithelial cells.
Entrez Gene
Summary This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:34109560-34815325
Strand Reverse strand
Band p11.21
Transcripts
ENST00000374789 ENSP00000363921
ENST00000374788 ENSP00000363920
ENST00000346874 ENSP00000340591
ENST00000350537 ENSP00000311986
ENST00000374790 ENSP00000363922
ENST00000374794 ENSP00000363926
ENST00000374776 ENSP00000363908
ENST00000374773 ENSP00000363905
ENST00000340077 ENSP00000341844
ENST00000374768 ENSP00000363900
ENST00000466092
ENST00000545693 ENSP00000443147
ENST00000545260 ENSP00000440857
ENST00000544292 ENSP00000444429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 87 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0019903 protein phosphatase binding
GO:0032266 phosphatidylinositol-3-phosphate binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0003383 apical constriction
GO:0006461 protein complex assembly
GO:0006612 protein targeting to membrane
GO:0007049 cell cycle
GO:0007163 establishment or maintenance of cell polarity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0008356 asymmetric cell division
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0022011 myelination in peripheral nervous system
GO:0031643 positive regulation of myelination
GO:0032970 regulation of actin filament-based process
GO:0034329 cell junction assembly
GO:0044319 wound healing, spreading of cells
GO:0045087 innate immune response (InnateDB)
GO:0045216 cell-cell junction organization
GO:0051642 centrosome localization
GO:0060341 regulation of cellular localization
GO:0070830 tight junction assembly
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0012505 endomembrane system
GO:0030054 cell junction
GO:0033269 internode region of axon
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0044295 axonal growth cone
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025812
View Gene Order
ENSBTAG00000014991
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_19373
Tight junction interactions pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_19331
Cell-cell junction organization pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04520
Adherens junction pathway
hsa04530
Tight junction pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.131489 Hs.618469
RefSeq NM_001184785 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619 XM_005252528 XM_005252534 XM_005252535 XM_006717471 XM_006717472 XM_006717473 XM_006717474 XM_006717475 XM_006717476 XM_006717477 XM_006717478
HUGO
OMIM
CCDS CCDS53509 CCDS53510 CCDS53511 CCDS53512 CCDS53513 CCDS53514 CCDS53515 CCDS53516 CCDS7178
HPRD 05994
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca