Version 5.4
Homo sapiens Gene: TJP2
Summary
InnateDB Gene IDBG-69307.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TJP2
Gene Name tight junction protein 2
Synonyms C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2
Species Homo sapiens
Ensembl Gene ENSG00000119139
Encoded Proteins
IDBP-69309
tight junction protein 2 (zona occludens 2)
IDBP-69311
tight junction protein 2 (zona occludens 2)
IDBP-69313
tight junction protein 2 (zona occludens 2)
IDBP-69315
tight junction protein 2 (zona occludens 2)
IDBP-372295
tight junction protein 2 (zona occludens 2)
IDBP-372317
tight junction protein 2 (zona occludens 2)
IDBP-596874
tight junction protein 2 (zona occludens 2)
IDBP-590806
tight junction protein 2 (zona occludens 2)
IDBP-807771
tight junction protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:69121264-69255208
Strand Forward strand
Band q21.11
Transcripts
ENST00000377259 ENSP00000366469
ENST00000377245 ENSP00000366453
ENST00000348208 ENSP00000345893
ENST00000265384 ENSP00000265384
ENST00000423935 ENSP00000402941
ENST00000453658 ENSP00000392178
ENST00000498204
ENST00000535702 ENSP00000442090
ENST00000539225 ENSP00000438262
ENST00000606364 ENSP00000475926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0010033 response to organic substance
GO:0035329 hippo signaling
GO:0046939 nucleotide phosphorylation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 tight junction
GO:0030054 cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024812
View Gene Order
ENSBTAG00000011770
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa04530
Tight junction pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.50382
RefSeq NM_001170414 NM_001170415 NM_001170416 NM_001170630 NM_004817 NM_201629 XM_005252311 XM_005252312 XM_005252313 XM_005252314 XM_005252315 XM_006717324
HUGO
OMIM
CCDS CCDS55314 CCDS55315 CCDS55316 CCDS55317 CCDS6627 CCDS6628
HPRD 06369
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca