Version 5.4
| Homo sapiens Gene: BTN3A3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-69364.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | BTN3A3 | ||||||||||||||||||
| Gene Name | butyrophilin, subfamily 3, member A3 | ||||||||||||||||||
| Synonyms | BTF3; BTN3.3 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000111801 | ||||||||||||||||||
| Encoded Proteins |
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
butyrophilin, subfamily 3, member A3
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
BTN3A3 is part of the BT3 family of immunoreceptors belonging to the extended B7 family that are expressed on the surface of resting and activated monocytes and monocyte-derived dendritic cells (iDC). BT3 molecules are involved in the regulation of the balance between immune activation and suppression.
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| Entrez Gene | |||||||||||||||||||
| Summary |
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:26440472-26453415 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p22.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.167741 | ||||||||||||||||||
| RefSeq | NM_001242803 NM_006994 NM_197974 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS4611 CCDS4612 | ||||||||||||||||||
| HPRD | 12548 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||