Version 5.4
Homo sapiens Gene: SAP130
Summary
InnateDB Gene IDBG-69376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAP130
Gene Name Sin3A-associated protein, 130kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136715
Encoded Proteins
IDBP-69378
Sin3A-associated protein, 130kDa
IDBP-69380
Sin3A-associated protein, 130kDa
IDBP-69382
Sin3A-associated protein, 130kDa
IDBP-385732
Sin3A-associated protein, 130kDa
IDBP-385734
Sin3A-associated protein, 130kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127941217-128028120
Strand Reverse strand
Band q14.3
Transcripts
ENST00000357702 ENSP00000350333
ENST00000259235 ENSP00000259235
ENST00000259234 ENSP00000259234
ENST00000424298 ENSP00000411634
ENST00000450957 ENSP00000414593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005634 nucleus
GO:0030914 STAGA complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024260
View Gene Order
ENSBTAG00000006003
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.32995
RefSeq NM_001145928 NM_024545 XM_005263767 XM_005263768 XM_005263769 XM_005263770 XM_006712748 XM_006712749
HUGO
OMIM
CCDS CCDS2153 CCDS54397
HPRD 18015
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca