Version 5.4
| Homo sapiens Gene: CASP5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-69591.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CASP5 | ||||||||||||||||||
| Gene Name | caspase 5, apoptosis-related cysteine peptidase | ||||||||||||||||||
| Synonyms | ICE(rel)III; ICEREL-III; ICH-3 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000137757 | ||||||||||||||||||
| Encoded Proteins |
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:104994235-105023168 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q22.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
NOD-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 838 | ||||||||||||||||||
| UniGene | Hs.213327 | ||||||||||||||||||
| RefSeq | NM_001136109 NM_001136110 NM_001136112 NM_004347 XM_006718925 | ||||||||||||||||||
| HUGO | HGNC:1506 | ||||||||||||||||||
| OMIM | 602665 | ||||||||||||||||||
| CCDS | CCDS44718 CCDS44719 CCDS44720 CCDS8328 | ||||||||||||||||||
| HPRD | 04048 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 838 | ||||||||||||||||||