Version 5.4
| Homo sapiens Gene: HIST1H2BJ | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-69798.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | HIST1H2BJ | ||||||||||||||||||
| Gene Name | histone cluster 1, H2bj | ||||||||||||||||||
| Synonyms | H2B/r; H2BFR; H2BJ | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000124635 | ||||||||||||||||||
| Encoded Proteins |
histone cluster 1, H2bj
histone cluster 1, H2bj
histone cluster 1, H2bj
histone cluster 1, H2bj
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:27125897-27132750 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p22.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Meiotic synapsis pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Packaging Of Telomere Ends pathway
Amyloids pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Opening pathway
Meiotic recombination pathway
HATs acetylate histones pathway
Cellular responses to stress pathway
PRC2 methylates histones and DNA pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Mitotic Prophase pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
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| KEGG |
Systemic lupus erythematosus pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P06899 | ||||||||||||||||||
| TrEMBL | B2R4S9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8347 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_003518 NM_021058 | ||||||||||||||||||
| HUGO | HGNC:4746 | ||||||||||||||||||
| OMIM | 602798 602804 602805 602807 602847 615044 | ||||||||||||||||||
| CCDS | CCDS4594 CCDS4618 | ||||||||||||||||||
| HPRD | 13657 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF531286 AF531288 AF531289 AF531290 AF531292 AF531293 AK311849 AK311935 AK312096 AL021807 AL031777 AL353759 BC001131 BC009612 BC096120 BC096122 BC096123 BC101653 BC101655 BC101748 BC101750 BC106899 CH471081 CH471087 M60750 X00088 Z80779 Z80780 Z80782 Z80783 | ||||||||||||||||||
| GenPept | AAA63189 AAH96120 AAH96122 AAH96123 AAI01654 AAI01656 AAI01749 AAI01751 AAI06900 AAN06686 AAN06688 AAN06689 AAN06690 AAN06692 AAN06693 BAG34791 BAG34876 BAG35032 CAA16949 CAA24950 CAB02541 CAB02542 CAB02544 CAB02545 CAC03411 CAC03417 CAC03420 CAC04130 EAW55530 EAW55531 EAW55537 EAW55543 EAW55545 EAW55554 EAX03080 | ||||||||||||||||||
| RNA Seq Atlas | 8339 8343 8344 8346 8347 | ||||||||||||||||||