Version 5.4
| Mus musculus Gene: Hist4h4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-703559.2 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Hist4h4 | ||||||||||||||||||
| Gene Name | histone cluster 4, H4 | ||||||||||||||||||
| Synonyms | 1700024H08Rik; H4; X04652 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000096010 | ||||||||||||||||||
| Encoded Proteins | |||||||||||||||||||
| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Feb 2014] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. [provided by RefSeq, Mar 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:136801553-136804431 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | G1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Meiotic Recombination pathway
Meiotic Synapsis pathway
RNA Polymerase I Transcription pathway
Oxidative Stress Induced Senescence pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Mus musculus biological processes pathway
Cell Cycle, Mitotic pathway
NoRC negatively regulates rRNA expression pathway
Chromatin organization pathway
Disease pathway
Chromosome Maintenance pathway
Signaling by Wnt pathway
HDMs demethylate histones pathway
Signaling by WNT in cancer pathway
Cellular responses to stress pathway
Amyloids pathway
HATs acetylate histones pathway
RNA Polymerase I Promoter Opening pathway
DNA Damage/Telomere Stress Induced Senescence pathway
PRC2 methylates histones and DNA pathway
Meiotic synapsis pathway
Telomere Maintenance pathway
Cell Cycle pathway
NoRC negatively regulates rRNA expression pathway
M Phase pathway
Condensation of Prophase Chromosomes pathway
Chromatin modifying enzymes pathway
formation of the beta-catenin:TCF transactivating complex pathway
Cellular Senescence pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Epigenetic regulation of gene expression pathway
Transcriptional regulation by small RNAs pathway
Packaging Of Telomere Ends pathway
TCF dependent signaling in response to WNT pathway
SIRT1 negatively regulates rRNA Expression pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Gene Expression pathway
DNA methylation pathway
Negative epigenetic regulation of rRNA expression pathway
Nucleosome assembly pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Regulatory RNA pathways pathway
RMTs methylate histone arginines pathway
Mitotic Prophase pathway
Signal Transduction pathway
Meiosis pathway
Meiotic recombination pathway
HDACs deacetylate histones pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Chain Elongation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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| KEGG |
Systemic lupus erythematosus pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Mm.246720 Mm.489077 | ||||||||||||||||||
| RefSeq | NM_175652 XM_006544099 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS39684 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | |||||||||||||||||||
| MGI Symbol | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||