Version 5.4
Homo sapiens Gene: IER3IP1
Summary
InnateDB Gene IDBG-704505.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IER3IP1
Gene Name
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000267228
Encoded Proteins
IDBP-726155
IDBP-811848
immediate early response 3 interacting protein 1
IDBP-811849
immediate early response 3 interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:47134656-47176281
Strand Reverse strand
Band q21.1
Transcripts
ENST00000588705 ENSP00000465194
ENST00000602459 ENSP00000473358
ENST00000602926 ENSP00000473502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:2000269 regulation of fibroblast apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 51124
UniGene
RefSeq
HUGO HGNC:18550
OMIM 609382
CCDS CCDS11933
HPRD
IMGT
EMBL AF125100 AF164798 AF371963 AL136667 BC010888 BC017391 CR533488
GenPept AAD39917 AAF80762 AAH10888 AAH17391 AAK53816 CAB66602 CAG38519
RNA Seq Atlas 51124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca