Version 5.4
Homo sapiens Gene: SPAG4
Summary
InnateDB Gene IDBG-70532.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG4
Gene Name sperm associated antigen 4
Synonyms CT127; SUN4
Species Homo sapiens
Ensembl Gene ENSG00000061656
Encoded Proteins
IDBP-70534
sperm associated antigen 4
IDBP-373349
sperm associated antigen 4
IDBP-373353
sperm associated antigen 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:35615892-35621049
Strand Forward strand
Band q11.22
Transcripts
ENST00000374273 ENSP00000363391
ENST00000454819 ENSP00000396670
ENST00000430878 ENSP00000399231
ENST00000463973
ENST00000462896
ENST00000468248
ENST00000498203
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0007283 spermatogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038180
View Gene Order
ENSBTAG00000006949
Not yet available
Cross-References
SwissProt
TrEMBL C9JJZ6
UniProt Splice Variant
Entrez Gene 6676
UniGene Hs.123159
RefSeq NM_003116 XM_005260519 XM_005260520 XM_006723864
HUGO HGNC:11214
OMIM 603038
CCDS CCDS13259
HPRD 04330
IMGT
EMBL AL109827
GenPept
RNA Seq Atlas 6676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca