Version 5.4
Mus musculus Gene: Noc2l
Summary
InnateDB Gene IDBG-705770.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Noc2l
Gene Name nucleolar complex associated 2 homolog (S. cerevisiae)
Synonyms AA410003; AF155546; NIR
Species Mus musculus
Ensembl Gene ENSMUSG00000095567
Encoded Proteins
IDBP-719188
IDBP-719179
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188976:
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:156236010-156247616
Strand Forward strand
Band E2
Transcripts
ENSMUST00000179543 ENSMUSP00000137253
ENSMUST00000179886 ENSMUSP00000137183
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0031493 nucleosomal histone binding
GO:0042393 histone binding
GO:0044822 poly(A) RNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002903 negative regulation of B cell apoptotic process
GO:0031497 chromatin assembly
GO:0032066 nucleolus to nucleoplasm transport
GO:0034644 cellular response to UV
GO:0035067 negative regulation of histone acetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188976
View Gene Order
ENSBTAG00000016528
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL J3QK52 Q8BHX6
UniProt Splice Variant
Entrez Gene 57741
UniGene Mm.423051 Mm.486684
RefSeq NM_021303
OMIM
CCDS CCDS57322
HPRD
IMGT
MGI ID MGI:1931051
MGI Symbol Noc2l
EMBL AK076287 CAAA01066805 CAAA01066806
GenPept BAC36289
RNA Seq Atlas 57741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca