InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pou3f2

Summary

InnateDB Gene

IDBG-707989.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou3f2

Gene Name

POU domain, class 3, transcription factor 2

Synonyms

9430075J19Rik; A230098E07Rik; Brn-2; Brn2; oct-7; OTF-7; Otf7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000095139

Encoded Proteins

IDBP-718274

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184486:
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:22482780-22488366

Strand

Reverse strand

Band

Transcripts

ENSMUST00000178174

ENSMUSP00000136147

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0014002	astrocyte development
GO:0014044	Schwann cell development
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021869	forebrain ventricular zone progenitor cell division
GO:0021979	hypothalamus cell differentiation
GO:0021985	neurohypophysis development
GO:0022011	myelination in peripheral nervous system
GO:0030182	neuron differentiation
GO:0040018	positive regulation of multicellular organism growth
GO:0045595	regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050770	regulation of axonogenesis
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000184486

View Gene Order

ENSBTAG00000024773

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.389520 Mm.405968 Mm.411421 Mm.486031 Mm.487599 Mm.487875 Mm.487894

RefSeq

NM_008899

OMIM

CCDS

CCDS18005

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas