Version 5.4
Homo sapiens Gene: TMC1
Summary
InnateDB Gene IDBG-70958.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMC1
Gene Name transmembrane channel-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165091
Encoded Proteins
IDBP-70960
transmembrane channel-like 1
IDBP-70962
transmembrane channel-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:72521801-72836351
Strand Forward strand
Band q21.13
Transcripts
ENST00000297784 ENSP00000297784
ENST00000340019 ENSP00000341433
ENST00000497073
ENST00000492418
ENST00000486417
ENST00000469455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006811 ion transport
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060005 vestibular reflex
GO:0060117 auditory receptor cell development
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0032426 stereocilium bundle tip
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024749
View Gene Order
ENSBTAG00000018778
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.670211
RefSeq NM_138691
HUGO
OMIM
CCDS CCDS6643
HPRD 05988
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca