Version 5.4
Homo sapiens Gene: NLRP11
Summary
InnateDB Gene IDBG-71154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRP11
Gene Name NLR family, pyrin domain containing 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179873
Encoded Proteins
IDBP-762941
IDBP-765862
IDBP-759804
IDBP-761140
IDBP-765034
IDBP-764661
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18648497
NLRP11 is a part of the NLRP (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing) family, has a role in apoptosis and inflammation.
Entrez Gene
Summary NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55785397-55836800
Strand Reverse strand
Band q13.43
Transcripts
ENST00000589093 ENSP00000466285
ENST00000593244 ENSP00000467988
ENST00000592953 ENSP00000468196
ENST00000589824 ENSP00000468082
ENST00000590409 ENSP00000466582
ENST00000593208 ENSP00000468696
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.375039
RefSeq NM_001297743 NM_145007 XM_005258632 XM_005258633
HUGO
OMIM
CCDS CCDS12935 CCDS74458
HPRD 10110
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca