Homo sapiens Gene: HIST1H2AL

Summary
InnateDB Gene IDBG-71165.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol HIST1H2AL
Gene Name histone cluster 1, H2al
Synonyms dJ193B12.9; H2A.i; H2A/i; H2AFI
Species Homo sapiens
Ensembl Gene ENSG00000198374
Encoded Proteins
IDBP-71167 histone cluster 1, H2al
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 27833034-27833606
Strand Forward strand
Band p22.1
Transcripts
ENST00000357320  ENSP00000349873
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein‑Protein  11
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0019899 enzyme binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P0C0S8 
TrEMBL A3KPC7 A4FTV9
UniProt Splice Variant
Entrez Gene 8329  8330  8332  8336  85235  8969 
UniGene Hs.233568
RefSeq NM_003511 
HUGO 4730 
OMIM 602787 602788 602793 602796
CCDS CCDS4634 
HPRD 09103
IMGT
EMBL AK311766 AK311941 AK312224 AK312232 AL009179 AL021807 AY131987 AY131988 AY131989 AY131991 AY131992 AY131993 BC016677 BC034487 BC069306 BC093849 BC093851 BC104198 BC104199 BC105129 BC112072 BC112254 BC112256 BC134366 BC148293 CH471081 L19778 X57138 X83549 Z83739 Z83742 Z98744
GenPept AAC24466  AAH16677  AAH34487  AAH69306  AAH93849  AAH93851  AAI04199  AAI04200  AAI05130  AAI12073  AAI12255  AAI12257  AAI34367  AAI48294  AAN59968  AAN59969  AAN59970  AAN59972  AAN59973  AAN59974  BAG34709  BAG34882  BAG35157  BAG35165  CAA15669  CAA16944  CAA16948  CAA40417  CAA58539  CAB06034  CAB06037  CAB11417  CAD24073  CAD24077  EAX03083  EAX03087  EAX03107  EAX03113  EAX03118  EAX03123 
ImmGen HIST1H2AL (murine) 
RNA Seq Atlas 8329  8330  8332  8336  85235  8969