InnateDB Gene
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IDBG-711816.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PCDHGB3
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Gene Name
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protocadherin gamma subfamily B, 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000262209
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Encoded Proteins
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protocadherin gamma subfamily B, 3
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome 5:141370264-141512979
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Strand
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Forward strand
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Band
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q31.3
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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UniGene
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RefSeq
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NM_018924
NM_032097
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HUGO
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OMIM
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CCDS
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CCDS58980
CCDS75334
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HPRD |
09391
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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