InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RORB

Summary

InnateDB Gene

IDBG-71213.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RORB

Gene Name

RAR-related orphan receptor B

Synonyms

bA133M9.1; NR1F2; ROR-BETA; RZR-BETA; RZRB

Species

Homo sapiens

Ensembl Gene

ENSG00000198963

Encoded Proteins

IDBP-71215

RAR-related orphan receptor B

IDBP-237993

RAR-related orphan receptor B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:74497365-74693177

Strand

Forward strand

Band

q21.13

Transcripts

ENST00000376896	ENSP00000366093
ENST00000396204	ENSP00000379507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007601	visual perception
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0035881	amacrine cell differentiation
GO:0042462	eye photoreceptor cell development
GO:0042752	regulation of circadian rhythm
GO:0043401	steroid hormone mediated signaling pathway
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046548	retinal rod cell development
GO:0046549	retinal cone cell development
GO:0048511	rhythmic process
GO:0060041	retina development in camera-type eye
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036192

View Gene Order

ENSBTAG00000021699

Not yet available

Pathways

NETPATH

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

hsa04710

Circadian rhythm pathway

INOH

PID NCI

Cross-References

SwissProt

Q92753

TrEMBL

UniProt Splice Variant

Entrez Gene

6096

UniGene

Hs.494178

RefSeq

NM_006914

HUGO

HGNC:10259

OMIM

601972

CCDS

CCDS6646

HPRD

09062

IMGT

EMBL

AL137018 BX647070 Y08639

GenPept

CAA69929 CAD13276

RNA Seq Atlas

6096