Version 5.4
Homo sapiens Gene: FXYD4
Summary
InnateDB Gene IDBG-71328.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXYD4
Gene Name FXYD domain containing ion transport regulator 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000150201
Encoded Proteins
IDBP-807092
FXYD domain containing ion transport regulator 4
IDBP-807097
FXYD domain containing ion transport regulator 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:43371642-43376335
Strand Forward strand
Band q11.21
Transcripts
ENST00000476166 ENSP00000473361
ENST00000480834
ENST00000479189
ENST00000616495 ENSP00000483791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt P59646
TrEMBL
UniProt Splice Variant
Entrez Gene 53828
UniGene
RefSeq NM_173160
HUGO HGNC:4028
OMIM
CCDS CCDS7203
HPRD
IMGT
EMBL AL512654 AY358584 BC054876
GenPept AAH54876 AAQ88947 CAI17065
RNA Seq Atlas 53828

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca