InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL35A

Summary

InnateDB Gene

IDBG-71902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL35A

Gene Name

ribosomal protein L35a

Synonyms

DBA5; L35A

Species

Homo sapiens

Ensembl Gene

ENSG00000182899

Encoded Proteins

IDBP-387308

ribosomal protein L35a

IDBP-387310

ribosomal protein L35a

IDBP-387311

ribosomal protein L35a

IDBP-387312

ribosomal protein L35a

IDBP-473524

ribosomal protein L35a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:197949987-197956610

Strand

Forward strand

Band

q29

Transcripts

ENST00000329092
ENST00000448864	ENSP00000393393
ENST00000429437	ENSP00000398058
ENST00000442341	ENSP00000387688
ENST00000439255	ENSP00000410683
ENST00000464167	ENSP00000419117
ENST00000485439
ENST00000496582
ENST00000474640

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042273	ribosomal large subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0070062	extracellular vesicular exosome