InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MRPL12

Summary

InnateDB Gene

IDBG-726099.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRPL12

Gene Name

mitochondrial ribosomal protein L12

Synonyms

5c5-2; L12mt; MRP-L31/34; MRPL7; MRPL7/L12; RPML12

Species

Homo sapiens

Ensembl Gene

ENSG00000262814

Encoded Proteins

IDBP-72549

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81703357-81707526

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000333676

ENSP00000333837

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.

Experimentally validated
Total	68 [view]
Protein-Protein	68 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

Biological Process

GO:0006390	transcription from mitochondrial promoter
GO:0006412	translation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005762	mitochondrial large ribosomal subunit
GO:0005840	ribosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000039640

View Gene Order

Pathways

NETPATH

REACTOME

REACT_200751

Organelle biogenesis and maintenance pathway

REACT_267673

Mitochondrial translation pathway

REACT_267680

Mitochondrial translation initiation pathway

REACT_267602

Mitochondrial translation termination pathway

REACT_267677

Mitochondrial translation elongation pathway

KEGG

hsa03010

Ribosome pathway

INOH

PID NCI

Cross-References

SwissProt

P52815

TrEMBL

A4UCS1 Q96Q74

UniProt Splice Variant

Entrez Gene

6182

UniGene

RefSeq

NM_002949

HUGO

HGNC:10378

OMIM

602375

CCDS

CCDS11785

HPRD

03849

IMGT

EMBL

AB051337 AF059736 AF105278 BC002344 BC007497 EF036488 X79865

GenPept

AAD16894 AAG32154 AAH02344 AAH07497 ABO65074 BAB54927 CAA56249

RNA Seq Atlas

6182