InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P4HB

Summary

InnateDB Gene

IDBG-72655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HB

Gene Name

prolyl 4-hydroxylase, beta polypeptide

Synonyms

DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB

Species

Homo sapiens

Ensembl Gene

ENSG00000185624

Encoded Proteins

IDBP-72657

prolyl 4-hydroxylase, beta polypeptide

IDBP-385473

prolyl 4-hydroxylase, beta polypeptide

IDBP-385476

prolyl 4-hydroxylase, beta polypeptide

IDBP-760185

IDBP-762986

IDBP-758638

IDBP-762611

IDBP-764431

IDBP-761669

IDBP-764299

IDBP-764401

IDBP-762239

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81843159-81860694

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000331483	ENSP00000327801
ENST00000415593	ENSP00000388117
ENST00000439918	ENSP00000388374
ENST00000473021
ENST00000476482
ENST00000474712
ENST00000478034
ENST00000472244
ENST00000484286
ENST00000477607
ENST00000467086
ENST00000471535
ENST00000466567
ENST00000570907	ENSP00000461362
ENST00000573778	ENSP00000460088
ENST00000576380	ENSP00000460285
ENST00000574914	ENSP00000460612
ENST00000571507
ENST00000571617	ENSP00000458300
ENST00000576390	ENSP00000461718
ENST00000575069	ENSP00000459211
ENST00000574007
ENST00000576541	ENSP00000460741
ENST00000576052	ENSP00000461791

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0016853	isomerase activity
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006457	protein folding
GO:0008152	metabolic process
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030198	extracellular matrix organization
GO:0034976	response to endoplasmic reticulum stress
GO:0042157	lipoprotein metabolic process
GO:0044281	small molecule metabolic process
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005886	plasma membrane
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome