Version 5.4
Homo sapiens Gene: CGB1
Summary
InnateDB Gene IDBG-728868.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CGB1
Gene Name chorionic gonadotropin, beta polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000267631
Encoded Proteins
IDBP-61881
chorionic gonadotropin, beta polypeptide 1
IDBP-246818
chorionic gonadotropin, beta polypeptide 1
IDBP-765056
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49035610-49036895
Strand Reverse strand
Band q13.33
Transcripts
ENST00000301407 ENSP00000301407
ENST00000391869 ENSP00000375742
ENST00000601167 ENSP00000472896
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3972
UniGene
RefSeq NM_033377 XM_005258478 NM_000894
HUGO HGNC:6584
OMIM 152780
CCDS CCDS12751 CCDS12748
HPRD 12307
IMGT
EMBL
GenPept
RNA Seq Atlas 3972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca