InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: JMJD7-PLA2G4B

Summary

InnateDB Gene

IDBG-7368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JMJD7-PLA2G4B

Gene Name

JMJD7-PLA2G4B readthrough

Synonyms

cPLA2-beta; HsT16992

Species

Homo sapiens

Ensembl Gene

ENSG00000168970

Encoded Proteins

IDBP-7372

JMJD7-PLA2G4B readthrough

IDBP-7374

JMJD7-PLA2G4B readthrough

IDBP-367760

JMJD7-PLA2G4B readthrough

IDBP-478754

JMJD7-PLA2G4B readthrough

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008] This gene transcribes naturally-occurring mRNAs that are read-through products of the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (PLA2G4B) genes. These read-through products contain in-frame segments from both genes but a function has yet to be determined for the predicted fusion proteins, which contain a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2011] This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:41828095-41848155

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000382448	ENSP00000371886
ENST00000342159	ENSP00000342785
ENST00000458483	ENSP00000416610
ENST00000487292	ENSP00000424127
ENST00000490848
ENST00000491746
ENST00000476036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004622	lysophospholipase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006954	inflammatory response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007567	parturition
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019722	calcium-mediated signaling
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0046475	glycerophospholipid catabolic process