InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RBL1

Summary

InnateDB Gene

IDBG-73739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBL1

Gene Name

retinoblastoma-like 1 (p107)

Synonyms

CP107; p107; PRB1

Species

Homo sapiens

Ensembl Gene

ENSG00000080839

Encoded Proteins

IDBP-73741

retinoblastoma-like 1 (p107)

IDBP-73743

retinoblastoma-like 1 (p107)

IDBP-595740

retinoblastoma-like 1 (p107)

IDBP-601174

retinoblastoma-like 1 (p107)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:36996349-37095995

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000373664	ENSP00000362768
ENST00000344359	ENSP00000343646
ENST00000525052	ENSP00000434711
ENST00000527999	ENSP00000437240

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	124 [view]
Protein-Protein	103 [view]
Protein-DNA	21 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0016568	chromatin modification
GO:0043550	regulation of lipid kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051726	regulation of cell cycle