Version 5.4
Homo sapiens Gene: SLC18A3
Summary
InnateDB Gene IDBG-74019.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC18A3
Gene Name solute carrier family 18 (vesicular acetylcholine), member 3
Synonyms VACHT
Species Homo sapiens
Ensembl Gene ENSG00000187714
Encoded Proteins
IDBP-74021
solute carrier family 18 (vesicular acetylcholine), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:49610301-49612720
Strand Forward strand
Band q11.23
Transcripts
ENST00000374115 ENSP00000363229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005277 acetylcholine transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0015870 acetylcholine transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15309
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q16572
TrEMBL
UniProt Splice Variant
Entrez Gene 6572
UniGene Hs.654374
RefSeq NM_003055
HUGO HGNC:10936
OMIM 600336
CCDS CCDS7231
HPRD
IMGT
EMBL AC073366 AK313094 BC007765 CH471187 U09210 U10554
GenPept AAA20497 AAB92675 AAH07765 BAG35918 EAW93093
RNA Seq Atlas 6572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca