Version 5.4
Homo sapiens Gene: SCN9A
Summary
InnateDB Gene IDBG-74205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCN9A
Gene Name sodium channel, voltage-gated, type IX, alpha subunit
Synonyms ETHA; FEB3B; GEFSP7; Nav1.7; NE-NA; NENA; PN1; SFNP
Species Homo sapiens
Ensembl Gene ENSG00000169432
Encoded Proteins
IDBP-74209
sodium channel, voltage-gated, type IX, alpha subunit
IDBP-293785
sodium channel, voltage-gated, type IX, alpha subunit
IDBP-293783
sodium channel, voltage-gated, type IX, alpha subunit
IDBP-387213
sodium channel, voltage-gated, type IX, alpha subunit
IDBP-387216
sodium channel, voltage-gated, type IX, alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:166195185-166375993
Strand Reverse strand
Band q24.3
Transcripts
ENST00000303354 ENSP00000304748
ENST00000409672 ENSP00000386306
ENST00000409435 ENSP00000386330
ENST00000454569 ENSP00000413212
ENST00000452182 ENSP00000393141
ENST00000472119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0031402 sodium ion binding
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006954 inflammatory response
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0048266 behavioral response to pain
GO:0055085 transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000075316
View Gene Order
ENSBTAG00000002425
Not yet available
Pathways
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.439145 Hs.714528
RefSeq NM_002977 XM_005246757
HUGO
OMIM
CCDS CCDS46441
HPRD 04565
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca