Homo sapiens Gene: SCN9A

Summary
InnateDB Gene IDBG-74205.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol SCN9A
Gene Name sodium channel, voltage-gated, type IX, alpha subunit
Synonyms ETHA; FEB3B; GEFSP7; Nav1.7; NE-NA; NENA; PN1; SFNP
Species Homo sapiens
Ensembl Gene ENSG00000169432
Encoded Proteins
IDBP-74207 sodium channel, voltage-gated, type IX, alpha subunit
IDBP-74209 sodium channel, voltage-gated, type IX, alpha subunit
IDBP-293785 sodium channel, voltage-gated, type IX, alpha subunit
IDBP-293783 sodium channel, voltage-gated, type IX, alpha subunit
IDBP-387213 sodium channel, voltage-gated, type IX, alpha subunit
IDBP-387216 sodium channel, voltage-gated, type IX, alpha subunit
Entrez Gene
Summary This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 167051695-167232503
Strand Reverse strand
Band q24.3
Transcripts
ENST00000375387  ENSP00000364536
ENST00000303354  ENSP00000304748
ENST00000409672  ENSP00000386306
ENST00000409435  ENSP00000386330
ENST00000454569  ENSP00000413212
ENST00000452182  ENSP00000393141
ENST00000472119 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0031402 sodium ion binding
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006954 inflammatory response
GO:0009636 response to toxin
GO:0009791 post-embryonic development
GO:0019228 regulation of action potential in neuron
GO:0048266 behavioral response to pain
GO:0055085 transmembrane transport
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0016020 membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000075316 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000002425 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15858 
TrEMBL E9PBA5 E9PF08 H7C064 Q53QP0
UniProt Splice Variant
Entrez Gene 6335 
UniGene Hs.439145 Hs.714528
RefSeq NM_002977 
HUGO 10597 
OMIM 603415
CCDS CCDS46441 
HPRD 04565
IMGT
EMBL AC074101 AC107082 AC108146 AJ310882 AJ310883 AJ310897 AJ580918 AJ580919 AY682084 AY682085 AY682086 DQ857292 X82835
GenPept AAT85833  AAT85834  AAT85835  AAY14794  ABI51981  CAA58042  CAC84537  CAC84550  CAC84551  CAE45644  CAE45645 
ImmGen SCN9A (murine) 
RNA Seq Atlas 6335