Homo sapiens Gene: SCN9A
Summary
InnateDB Gene IDBG-74205.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol SCN9A
Gene Name sodium channel, voltage-gated, type IX, alpha subunit
Synonyms ETHA; FEB3B; GEFSP7; Nav1.7; NE-NA; NENA; PN1; SFNP;
Species Homo sapiens
Ensembl Gene ENSG00000169432
Encoded Proteins
sodium channel, voltage-gated, type IX, alpha subunit
sodium channel, voltage-gated, type IX, alpha subunit
sodium channel, voltage-gated, type IX, alpha subunit
sodium channel, voltage-gated, type IX, alpha subunit
sodium channel, voltage-gated, type IX, alpha subunit
sodium channel, voltage-gated, type IX, alpha subunit
Protein Structure
Entrez Gene
Summary This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:167051695-167232503
Strand Reverse strand
Band q24.3
Transcripts
ENST00000375387 ENSP00000364536
ENST00000303354 ENSP00000304748
ENST00000409672 ENSP00000386306
ENST00000409435 ENSP00000386330
ENST00000454569 ENSP00000413212
ENST00000452182 ENSP00000393141
ENST00000472119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0031402 sodium ion binding
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006954 inflammatory response
GO:0009636 response to toxin
GO:0009791 post-embryonic development
GO:0019228 regulation of action potential in neuron
GO:0048266 behavioral response to pain
GO:0055085 transmembrane transport
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0016020 membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q15858
TrEMBL E9PBA5 E9PF08 H7C064 Q53QP0
UniProt Splice Variant
Entrez Gene 6335
UniGene Hs.439145 Hs.714528
RefSeq NM_002977
HUGO 10597
OMIM 603415
CCDS CCDS46441
HPRD 04565
IMGT
EMBL AC074101 AC107082 AC108146 AJ310882 AJ310883 AJ310897 AJ580918 AJ580919 AY682084 AY682085 AY682086 DQ857292 X82835
GenPept AAT85833 AAT85834 AAT85835 AAY14794 ABI51981 CAA58042 CAC84537 CAC84550 CAC84551 CAE45644 CAE45645
ImmGen SCN9A (murine)
RNA Seq Atlas 6335