Version 5.4
Homo sapiens Gene: DPAGT1
Summary
InnateDB Gene IDBG-74265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPAGT1
Gene Name dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Synonyms ALG7; CDG-Ij; CDG1J; CMSTA2; D11S366; DGPT; DPAGT; DPAGT2; G1PT; GPT; UAGT; UGAT
Species Homo sapiens
Ensembl Gene ENSG00000172269
Encoded Proteins
IDBP-74267
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
IDBP-244847
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
IDBP-293573
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
IDBP-383894
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
IDBP-383895
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119096503-119108331
Strand Reverse strand
Band q23.3
Transcripts
ENST00000354202 ENSP00000346142
ENST00000392834 ENSP00000376579
ENST00000409993 ENSP00000386597
ENST00000414373 ENSP00000402019
ENST00000442480 ENSP00000406591
ENST00000445653
ENST00000481084
ENST00000461999
ENST00000460183
ENST00000472016
ENST00000525456
ENST00000524658
ENST00000530052
ENST00000533687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006487 protein N-linked glycosylation
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019348 dolichol metabolic process
GO:0019408 dolichol biosynthetic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051259 protein oligomerization
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032123
View Gene Order
ENSBTAG00000005371
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9H3H5
TrEMBL A0A024R3H8
UniProt Splice Variant
Entrez Gene 1798
UniGene Hs.524081
RefSeq NM_001382
HUGO HGNC:2995
OMIM 191350
CCDS CCDS8411
HPRD 01879
IMGT
EMBL AF069061 AF070443 BC000325 BC047771 BT006802 CH471065 Z82022
GenPept AAG43168 AAH00325 AAH47771 AAP35448 CAB04787 EAW67452 EAW67453 EAW67454 EAW67455
RNA Seq Atlas 1798

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca