InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGEF12

Summary

InnateDB Gene

IDBG-74643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF12

Gene Name

Rho guanine nucleotide exchange factor (GEF) 12

Synonyms

LARG; PRO2792

Species

Homo sapiens

Ensembl Gene

ENSG00000196914

Encoded Proteins

IDBP-74645

Rho guanine nucleotide exchange factor (GEF) 12

IDBP-234420

Rho guanine nucleotide exchange factor (GEF) 12

IDBP-588671

Rho guanine nucleotide exchange factor (GEF) 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120336914-120489936

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000356641	ENSP00000349056
ENST00000397843	ENSP00000380942
ENST00000532993	ENSP00000432984
ENST00000529970
ENST00000530388
ENST00000528225
ENST00000525960
ENST00000532823
ENST00000525222
ENST00000530747
ENST00000531616
ENST00000526067
ENST00000528681
ENST00000612968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway