InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DKK1

Summary

InnateDB Gene

IDBG-74684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DKK1

Gene Name

dickkopf 1 homolog (Xenopus laevis)

Synonyms

DKK-1; SK

Species

Homo sapiens

Ensembl Gene

ENSG00000107984

Encoded Proteins

IDBP-74686

dickkopf homolog 1 (Xenopus laevis)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:52314296-52318042

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000373970	ENSP00000363081
ENST00000467359
ENST00000494277
ENST00000476752

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0048019	receptor antagonist activity
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000904	cell morphogenesis involved in differentiation
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0001942	hair follicle development
GO:0002090	regulation of receptor internalization
GO:0007275	multicellular organismal development
GO:0007492	endoderm development
GO:0030111	regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0030514	negative regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0031333	negative regulation of protein complex assembly
GO:0032526	response to retinoic acid
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042662	negative regulation of mesodermal cell fate specification
GO:0042663	regulation of endodermal cell fate specification
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0060323	head morphogenesis
GO:0060325	face morphogenesis
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:1900116	extracellular negative regulation of signal transduction
GO:1901296	negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:2000726	negative regulation of cardiac muscle cell differentiation