Version 5.4
Homo sapiens Gene: LBP
Summary
InnateDB Gene IDBG-74721.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LBP
Gene Name lipopolysaccharide binding protein
Synonyms BPIFD2
Species Homo sapiens
Ensembl Gene ENSG00000129988
Encoded Proteins
IDBP-74723
lipopolysaccharide binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:38346356-38377023
Strand Forward strand
Band q11.23
Transcripts
ENST00000217407 ENSP00000217407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0070891 lipoteichoic acid binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002281 macrophage activation involved in immune response
GO:0006953 acute-phase response
GO:0006968 cellular defense response
GO:0008228 opsonization
GO:0015920 lipopolysaccharide transport
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032490 detection of molecule of bacterial origin
GO:0032496 response to lipopolysaccharide
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043032 positive regulation of macrophage activation
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0060265 positive regulation of respiratory burst involved in inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016024
View Gene Order
ENSBTAG00000016864
Not yet available
Pathways
NETPATH
REACTOME
REACT_6822
Transfer of LPS from LBP carrier to CD14 pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
KEGG
hsa04620
Toll-like receptor signaling pathway pathway
INOH
INOH website
Toll-like receptor signaling pathway pathway
PID NCI
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt P18428
TrEMBL
UniProt Splice Variant
Entrez Gene 3929
UniGene Hs.154078
RefSeq NM_004139
HUGO HGNC:6517
OMIM 151990
CCDS CCDS13304
HPRD
IMGT
EMBL AF013500 AF013501 AF013502 AF013503 AF013504 AF013505 AF013506 AF013507 AF013508 AF013509 AF013510 AF013511 AF013512 AF105067 AK313625 AL080249 CH471077 L42172 M35533 X98657 X98658 X98659 X98660 X98661 X98662 X98663 X98664 X98665 X98666 X98667 X98668
GenPept AAA59493 AAA66446 AAC39547 AAD21962 BAG36385 CAA67226 CAC10462 EAW76034
RNA Seq Atlas 3929

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca