InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNJ4

Summary

InnateDB Gene

IDBG-7481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ4

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 4

Synonyms

HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3

Species

Homo sapiens

Ensembl Gene

ENSG00000168135

Encoded Proteins

IDBP-7483

potassium inwardly-rectifying channel, subfamily J, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:38426327-38455199

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000303592

ENSP00000306497

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0030659	cytoplasmic vesicle membrane
GO:0045211	postsynaptic membrane