InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGA6

Summary

InnateDB Gene

IDBG-75102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA6

Gene Name

integrin, alpha 6

Synonyms

CD49f; ITGA6B; VLA-6

Species

Homo sapiens

Ensembl Gene

ENSG00000091409

Encoded Proteins

IDBP-75106

integrin, alpha 6

IDBP-293623

integrin, alpha 6

IDBP-293619

integrin, alpha 6

IDBP-387565

integrin, alpha 6

IDBP-387576

integrin, alpha 6

IDBP-387577

integrin, alpha 6

IDBP-387578

integrin, alpha 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:172427354-172506282

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000264107	ENSP00000264107
ENST00000409080	ENSP00000386896
ENST00000409532	ENSP00000386614
ENST00000412899	ENSP00000413470
ENST00000458358	ENSP00000394169
ENST00000442250	ENSP00000406694
ENST00000416789	ENSP00000388435
ENST00000497107
ENST00000469534
ENST00000470259
ENST00000475302

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043236	laminin binding
GO:0046872	metal ion binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0031589	cell-substrate adhesion
GO:0031668	cellular response to extracellular stimulus
GO:0033627	cell adhesion mediated by integrin
GO:0034329	cell junction assembly
GO:0042327	positive regulation of phosphorylation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046847	filopodium assembly
GO:0050873	brown fat cell differentiation
GO:0050900	leukocyte migration
GO:0071407	cellular response to organic cyclic compound
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0030056	hemidesmosome
GO:0030175	filopodium
GO:0034676	alpha6-beta4 integrin complex
GO:0045178	basal part of cell